New Research


Biomechanics simulation for integrating mechanical engineering and medicine

Professor Shigeo Wada, Associate Professor Hiroshi Miyazaki, Assistant Professor Kenichiro Koshiyama

   In our group, through both the analytical approach by experiments and the synthetic approach by computer simulations, we investigate the mechanical properties and the biological functions of living body from cells to organisms, and clarify the mechanical adaptation and remodeling which are essential in the biological system. Based on those understandings, we aim to develop an innovative computer-aided system for diagnosis, treatment and prediction of diseases.
   Figure A demonstrates an image-based simulation of the lung respiration which links the medical images with the computational analysis. The oxygen concentration in the airway was calculated using a realistic lung model and superimposed upon the CT image. The addition of physical quantities to the anatomical information greatly assists the clinical diagnosis. Furthermore, we attempt multi-scale analysis of the lung mechanics by developing a mathematical model of microstructure of the lung consisting of alveoli and a mechanical model of the cell and tissue (B).
   Figure C and D show a multi-scale simulation of blood flow to understand and predict the rupture of red blood cells in the axial flow pump to assist the cardiac output. We simulated the deformation of the red blood cell using computational fluid dynamics in conjunction with a red blood cell model based on the minimum energy principle (C). We also analyzed the rupture of the cell membrane by expansion in the molecular scales (D). Please visit our website for more information.

Fig. A: Realistic anatomical model of the lung and airway and the oxygen concentration in the airway obtained by image-based simulation. B: Lung microstructure obtained by phase field model and the deformation of cell and tissue in the alveolar wall. C: Red blood cell deformation in the blood flow through the axial flow pump. D: Molecular dynamics simulation of rupture of the red blood cell membrane.

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